Livcare 5mg Tablet is used to treat a liver disease that gradually destroys the bile ducts in the liver.
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Obeticholic Acid is a medication prescribed for the treatment of primary biliary cirrhosis, a liver condition that hampers proper liver function and leads to an accumulation of bile within the liver. This drug operates by reducing bile production in the liver and enhancing the removal of bile from the organ.
While taking Obeticholic Acid, you may experience side effects such as abdominal discomfort, constipation, dizziness, and fatigue, among others. Typically, these side effects subside over time. If they persist or worsen, it's advisable to seek advice from your healthcare provider. It's crucial to avoid using this medication if you have an allergy to it.
Obeticholic Acid can be ingested with or without food. Your doctor will determine the suitable dosage and treatment duration based on your medical condition and how you respond to the treatment. Do not discontinue using this medicine without consulting your physician.
If you have existing liver issues, use Obeticholic Acid cautiously. To prevent potential drug interactions, inform your doctor of any other medications you may be taking before commencing Obeticholic Acid treatment. If you are pregnant or breastfeeding, consult your healthcare provider before starting this medication.
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Livcare 5mg Tablet is not recommended for use in pregnant women. Consult your doctor before taking Livcare 5mg Tablet.
It is not known whether the Livcare 5mg Tablet passes through breast milk. Consult your doctor before taking Livcare 5mg Tablet.
Livcare 5mg Tablet has no or negligible influence on your ability to drive or use machines.
Please consult your doctor if you have kidney impairment or any concerns regarding this.
Livcare 5mg Tablet is not recommended for use in patients with complete blockage of the biliary tract (liver, gall bladder, and bile ducts). Consult your doctor before taking Livcare 5mg Tablet.
Primary biliary cirrhosis
Obeticholic Acid works by decreasing the production of bile in the liver and promoting the removal of bile from your liver.
Obiholic Tablet is used for the treatment of a liver disease called primary biliary cirrhosis in adults.
Obeticholic acid's mechanism of action involves its interaction with the Farnesoid X receptor (FXR) in the liver and gut. FXR is a nuclear receptor that plays a critical role in regulating various metabolic processes, including bile acid synthesis, bile acid transport, lipid metabolism, and glucose regulation.
Here's a summary of how obeticholic acid's action improves liver function:
Obeticholic Acid is indicated for the treatment of primary biliary cholangitis (PBC) in adults. It can be used in combination with ursodeoxycholic acid (UDCA) in adults who have had an inadequate response to UDCA for at least one year, or as monotherapy in adults who cannot tolerate UDCA.
The dosing instructions for Obeticholic Acid are important for individuals with primary biliary cholangitis (PBC) and healthcare providers to understand. The dosing can vary based on the patient's liver condition, as assessed by the Child-Pugh classification, as well as their response to the medication. Here are the key points:
Concomitant Bile-Acid Binding Resin: If a patient is taking a bile-acid binding resin, it's recommended to separate the doses of Obeticholic Acid by at least 4 hours to avoid potential interactions that may reduce Obeticholic Acid absorption and efficacy.
Child-Pugh Classification: Before initiating Obeticholic Acid, it's important to determine the patient's Child-Pugh classification. This classification system assesses the severity of liver disease and helps determine the appropriate starting dosage.
Starting Dose and Titration: The dosing recommendations are based on the patient's Child-Pugh classification:
For noncirrhotic or compensated Child-Pugh class A patients:
For patients with Child-Pugh class B or C, or those with a prior decompensation event:
These dosing guidelines are important for optimizing the treatment of PBC with Obeticholic Acid while considering the patient's liver condition and response to the medication.
Administration: Obeticholic Acid can be taken with or without food.
Drug-Drug Interactions: Obeticholic Acid may interact with xanthines (theophylline), muscle relaxants (tizanidine), blood thinners (warfarin), bile acid sequestrants (cholestyramine, colestipol, colesevelam).
Drug-Food Interactions: No interactions found/established.
Drug-Disease Interactions: Inform your doctor if you have biliary obstruction, liver impairment, or lipid disorder.
Livcare 5mg Tablet is not recommended for use in pregnant women and it is not known whether Livcare 5mg Tablet passes through breast milk.
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